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In the OCTN2 occluded conformation, R471 is involved in a hydrogen bonding interaction with S467, coordinating both the hydroxyl and the backbone carbonyl at the point where the lower segment of TM11 kinks toward TM2 in the occluded conformation

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EGFR is a similar tyrosine kinase receptor as c-MET has been reported to be highly expressed in 90% of the HNSCC patients

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